📄 Category

cancer biology

411 papers

Single cell multiomics reveal clonal and functional dynamics of MDS stem/progenitor cells during hypomethylating therapy

This study utilizes single-cell multiomics to reveal that azacitidine treatment in myelodysplastic neoplasms drives partial hematopoietic regeneration through the expansion of genetically stable stem/progenitor cells while suppressing malignant clones, yet eventual disease progression is fueled by the persistence of refractory sub-populations whose in vivo resistance is modulated by cell-extrinsic factors.

Thoms, J. A. I., Hampton, H. R., Boon, P. L. S. + 16 more2026-03-13📄 cancer biology

Predicting targeted- and immunotherapeutic response outcomes in melanoma with single-cell Raman Spectroscopy and AI

This study demonstrates that a non-destructive, single-cell Raman spectroscopy approach combined with machine learning can accurately differentiate melanoma cell phenotypes and predict therapeutic resistance to targeted and immunotherapies in both cell lines and patient-derived samples, offering a rapid and scalable tool for precision medicine.

Chang, K., Serasanambati, M., Ogunlade, B. + 16 more2026-03-12📄 cancer biology

Physiological cerebrospinal fluid like medium reveals autophagy dependency of leukaemia in the central nervous system

By developing a physiological cerebrospinal fluid-like culture medium (CSFmax) that accurately mimics the CNS metabolic niche, researchers identified autophagy as a critical therapeutic vulnerability in central nervous system acute lymphoblastic leukemia, demonstrating that inhibiting this pathway significantly reduces disease burden in preclinical models.

Himonas, E., Manoharan, A., Roy, K. + 10 more2026-03-12📄 cancer biology

Spatial Landscape of Pregnancy-Associated Triple Negative Breast Cancer and Mammary Gland Involution

This study utilizes spatial transcriptomics to reveal that post-lactational involution drives distinct inflammatory and immune-exhausted transcriptional programs in pregnancy-associated triple-negative breast cancer, highlighting the critical need for early detection in morphologically normal epithelium and TME-targeted therapies for women diagnosed within three years of delivery.

Veraksa, D., Mukund, K., Frankhouser, D. + 11 more2026-03-12📄 cancer biology

Systemic neoantigen-specific T cells reveal central determinants of PD-(L)1 blockade efficacy

This study demonstrates that while CD4+ T cell responses correlate with neoantigen availability, the magnitude and breadth of systemic, functionally engaged CD8+ T cell responses against neoantigens are the central determinants of clinical benefit and survival in patients with non-small cell lung cancer treated with PD-(L)1 blockade, independent of tumor mutational burden.

Ramade, C., Thebault, N., Scarlata, C.-M. + 30 more2026-03-12📄 cancer biology

An Organotypic Oral Squamous Cell Carcinoma Model Recapitulates Epithelial-Stromal Complexity at Single-cell Resolution and Reveals Matrix-derived Signalling as a Therapeutic Target.

This study validates a 3D organotypic head and neck squamous cell carcinoma model using single-cell RNA sequencing to demonstrate its high fidelity in recapitulating in vivo epithelial-stromal complexity and identifies matrix-derived signaling as a critical therapeutic target.

Yevlashevskaya, O. S., Davies, J. Z., Choi, J. + 5 more2026-03-12📄 cancer biology

Addition of chemotherapy to radiotherapy promotes progenitor-exhausted CD8⁺ T-cell clonal dominance in head and neck cancer

This study demonstrates that adding chemotherapy to radiotherapy in head and neck cancer uniquely drives the clonal expansion of progenitor-exhausted CD8⁺ T-cells rather than terminally exhausted ones, suggesting a distinct immunological remodeling that offers a strategic window for optimizing combination immunotherapy.

Chan Wah Hak, C., Patrikeev, A., Rullan, A. + 19 more2026-03-12📄 cancer biology

WITHDRAWN: A Druggable Tumor Suppressor and Leukemic Stem Cell Marker

This study identifies the absence of the tumor suppressor AT2R as a key marker for chemotherapy-resistant leukemic stem cells in acute myeloid leukemia, demonstrating that epigenetic silencing of AT2R drives disease progression through fatty acid metabolism and that its pharmacological activation with the agonist buloxibutid (C21) effectively inhibits leukemogenesis and enhances chemotherapy efficacy.

Pan, Y., Wang, C., Meng, X. + 5 more2026-03-11📄 cancer biology

Targeting NF-κB epigenetic activation and DNA repair deficiency in G34-mutant pediatric diffuse hemispheric glioma with nanoparticles combining PARP inhibition and immune stimulation mediated by CpG dinucleotides

This study demonstrates that G34-mutant pediatric diffuse hemispheric gliomas can be targeted by HDL nanoparticles co-delivering CpG dinucleotides to stimulate NF-κB-mediated immune responses and olaparib to exploit DNA repair deficiencies, thereby offering a promising therapeutic strategy for these aggressive tumors.

Haase, S., Banerjee, K., Mujeeb, A. A. + 9 more2026-03-11📄 cancer biology